Response Options to “Histologic Type”

___ Endometrioid carcinoma, NOS

___ Endometrioid carcinoma with squamous differentiation

___ Endometrioid carcinoma, villoglandular variant

___ Endometrioid carcinoma with secretory differentiation

___ Endometrioid carcinoma, other variant (specify): _________________

___ Serous endometrial intraepithelial carcinoma

___ Serous carcinoma

___ Carcinosarcoma (malignant mixed Müllerian tumor)

___ Mucinous carcinoma (Note: carcinoma in which >50% of the neoplasm is mucinous)

___ Clear cell carcinoma

___ Small cell neuroendocrine carcinoma

___ Large cell neuroendocrine carcinoma

___ Mixed cell carcinoma (specify types and percentages): (Note: two or more distinctive types, each representing at least 5% of the tumor)_______________________________

___ Undifferentiated carcinoma

___ Dedifferentiated carcinoma

___ Other histologic type not listed (specify): ____________________________

FIGO Architectural Grading:

Grade 1        5% or less nonsquamous solid growth pattern

Grade 2        6% to 50% nonsquamous solid growth pattern

Grade 3        > 50% nonsquamous solid growth pattern

Notable nuclear atypia (according to the WHO, grade 3 nuclei involving greater than 50% of the tumor), which exceeds that which is routinely expected for the architectural grade, increases the tumor grade by 1.

In addition, the following guidelines should be used in grading:

(1) The squamous component of endometrioid adenocarcinoma should not be graded because the degree of differentiation typically parallels that of the glandular component.

(2) Because mucinous carcinomas are closely related to endometrioid carcinomas, they can be graded by the same criteria.

(3) Serous, clear cell, transitional, small cell and large cell neuroendocrine carcinomas, undifferentiated/dedifferentiated carcinomas, and carcinosarcomas are generally considered to be high grade and it is not recommended to assign a FIGO grade to these tumor types.  When the case summary is being completed, these should be designated as “not applicable” for histologic grade.

(4) In mixed carcinomas, the highest grade should be assigned.

Response Options to “Other Tissue/ Organ Involvement” (select all that apply)

Note: Any organ not selected is either not involved or was not submitted.

___ Not applicable

___ Not identified

___ Right ovary

___ Left ovary

___ Ovary (side not specified)

___ Right fallopian tube

___ Left fallopian tube

___ Fallopian tube (side not specified)

___ Vagina

___ Right parametrium

___ Left parametrium

___ Parametrium (side not specified)

___ Pelvic wall

___ Bladder wall

___ Bladder mucosa

___ Rectal wall

___ Bowel mucosa

___ Omentum

___ Other organs/tissue (specify): ________________

___ Cannot be determined (explain):_________________________

**Note: Lymph nodes designated as pelvic, parametrial, obturator, internal iliac (hypogastric), external iliac, common iliac, sacral, presacral and para-aortic are considered regional lymph nodes. Any other involved nodes should be categorized as metastases (pM1) and commented on in the distant metastasis section. Presence of isolated tumor cells no greater than 0.2 mm in regional lymph node(s) is considered N0 (i+). Reporting the number of lymph nodes with isolated tumor cells is required only in the absence of macrometastasis or micrometastasis in other lymph nodes.

Gynecologic

Staging

Click here to leave feedback