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Response Options to “Tumor Location”

__ Entirely above anterior peritoneal reflection

__ Entirely below anterior peritoneal reflection

__ Straddles anterior peritoneal reflection

­­__ Not specified


Response Options to “Specify type of vascular invasion”

__ Small vessel

__ Large vessel (venous)

__ Intramural

__ Extramural


**Tumor Budding - The presence of single cells or small clusters of less than five cells at the advancing front of the tumor is considered as peritumoral tumor budding.



Response Options to "tumor extension"

___ Cannot be assessed 

___ No evidence of primary tumor

___ Carcinoma in situ, intraepithelial; no invasion of lamina propria 

___ Intramucosal carcinoma, invasion of lamina propria/muscularis mucosae 

___ Tumor invades submucosa 

___ Tumor invades muscularis propria

___ Tumor invades through the muscularis propria into pericolorectal tissues

___ Tumor penetrates to the surface of the visceral peritoneum/serosa 

___ Tumor is adherent to other organs or structures (specify: _____)

___ Tumor directly invades adjacent structures (specify: _____)

Response Options to "Macroscopic intactness of mesorectum"

___ Not applicable

___ Complete

___ Near complete

___ Incomplete

___ Cannot be determined

Options for treatment effect

Modified Ryan Scheme for Tumor Regression Score47

Description

Tumor Regression Score

No viable cancer cells (complete response)

0

Single cells or rare small groups of cancer cells (near complete response)

1

Residual cancer with evident tumor regression, but more than single cells or rare small groups of cancer cells (partial response)

2

Extensive residual cancer with no evident tumor regression (poor or no response)

3


Gastrointestinal


Staging


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