Pathologic Staging (pTNM) CAP approved Ophthalmic – Retinoblastoma 4.0.0.0 (AJCC 8th Ed.)

TNM Descriptors (required only if applicable) (select all that apply)

___ m (multiple primary tumors)

___ r (recurrent)

___ y (posttreatment)

Primary Tumor (pT)

___ pTX: Unknown evidence of intraocular tumor 

___ pT0: No evidence of intraocular tumor 

___ pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre- or intralaminar involvement of the optic nerve head 

___ pT2:   Intraocular tumor(s) with local invasion  

___ pT2a: Concomitant focal choroidal invasion and pre- or intralaminar involvement of the optic nerve head 

___ pT2b Tumor invasion of stroma of iris and/or trabecular meshwork and/or Schlemm’s canal

___ pT3:   Intraocular tumor(s) with significant local invasion 

___ pT3a Massive choroidal invasion (>3 mm in largest diameter, or multiple foci of focal choroidal involvement totaling >3 mm, or any full-thickness choroidal involvement)

___ pT3b: Retrolaminar invasion of the optic nerve head, not involving the transected end of the optic nerve 

___ pT3c: Any partial-thickness involvement of the sclera within the inner two thirds

___ pT3d: Full-thickness invasion into the outer third of the sclera and/or invasion into or around emissary channels

___ pT4: Evidence of extraocular tumor: tumor at the transected end of the optic nerve, tumor in the meningeal spaces around the optic nerve, full-thickness invasion of the sclera with invasion of the episclera, adjacent adipose tissue, extraocular muscle, bone, conjunctiva, or eyelids

Regional Lymph Nodes (pN)

___ pNX: Regional lymph nodes cannot be assessed 

___ pN0:  No regional lymph node involvement

___ pN1:  Regional lymph node involvement 

Distant Metastasis (pM) (required only if confirmed pathologically in this case)

___ pM1: Distant metastasis with histopathologic confirmation 

___ pM1a: Histopathologic confirmation of tumor at any distant site (eg, bone marrow, liver, or other)

___ pM1b: Histopathologic confirmation of tumor in the cerebrospinal fluid or CNS parenchyma  Specify site(s), if known:

Ophthalmic

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