Pathologic Staging

CAP Approved Pediatric • Rhabdomyosarcoma 3.1.0.0

The Intergroup Rhabdomyosarcoma Study Postsurgical Clinical Grouping System

Note: Clinical information required to definitively assign stage group (eg, gross residual disease or distant metastatic disease) may not be available to the pathologist. Alternatively, this protocol may not be applicable to some situations (eg, group IIIA). If applicable, the appropriate stage group may be assigned by the pathologist.

___ Not applicable

___ Cannot be assessed (see Comment)

Group I

___ A        Localized tumor, confined to site of origin, completely resected

___ B        Localized tumor, infiltrating beyond site of origin, completely resected

Group II

___ A        Localized tumor, gross total resection, but with microscopic residual disease

___ B        Locally extensive tumor (spread to regional lymph nodes), completely

resected

___ C        Locally extensive tumor (spread to regional lymph nodes), gross total

resection, but microscopic residual disease

Group III

___ A        Localized or locally extensive tumor, gross residual disease after biopsy only

___ B        Localized or locally extensive tumor, gross residual disease after major

resection (greater than 50% debulking)

Group IV

___        Any size primary tumor, with or without regional lymph node involvement,

with distant metastases, without respect to surgical approach to primary

tumor.

Pediatric

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