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Comments (Pharynx)
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Comments (Pharynx)
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Recommendations for HPV DNA Testing in Oropharyngeal Squamous Cell Carcinoma
Based on Morphology and p16 Staining Profile
|
Morphology |
p16 |
Requires HPV DNA Testing Confirmation |
|
Nonkeratinizing or predominantly nonkeratinizing |
Strong and diffuse (cytoplasmic and nuclear, ie, >70%) |
No |
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Nonkeratinizing or predominantly nonkeratinizing |
Negative or only focally positive |
Yes |
|
Keratinizing |
Strong and diffuse (cytoplasmic and nuclear, ie, >70%) |
Yes |
|
Keratinizing |
Negative or only focally positive |
No |