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Pharynx
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Pharynx
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Pharynx (SPHYX) (PLEASE ENSURE p16/HPV STATUS IS AVAILABLE FOR OROPHARYNX pTNM STAGING)
- For resection specimens with invasive carcinomas of the pharynx (oropharynx, nasopharynx, hypopharynx) including the base of tongue, tonsils, soft palate, and uvula. Mucosal melanoma is included. Lymphomas and sarcomas are not included.
Specimen and Surgical Procedure
Specimen, laterality, procedure.......................................................
Lymph node submitted and/or identified in the specimen……….yes/no
Tumor
Tumor site...................................................................................
Tumor laterality................................................ R/L/bilateral/midline/not specified
Tumor focality........................................ unifocal/bilateral/multifocal (specify:___)
Tumor size...................................................................................
Histologic type..............................................................................
Histologic grade............................................................................
Lymphovascular invasion.............................................................. present/absent Perineural invasion...................................................................... present/absent
Final margins
Uninvolved by invasive tumor
Distance from closest margin (millimeters): ____ mm
Location of closest margin: ___
Other uninvolved margins (list all):__
Involved by invasive tumor
Location of margin(s): ___
Uninvolved by high-grade dysplasia/in situ disease
Distance from closest margin (millimeters): ____ mm
Location of closest margin: ___
Other uninvolved margins (list all):__
Involved by high-grade dysplasia/in situ disease
Location of margin(s): ___
Lymph Nodes
Regional lymph nodes involved....................................... __
Regional lymph nodes examined...................................... __
Laterality of Lymph Nodes Involved…… Ipsilateral (including midline)/Contralateral/Bilateral
Size of largest metastatic focus (in cm)........................................... __cm
Extranodal extension (ENE)................................................................... present/absent
Ancillary Studies
p16 immunohistochemistry*..............................................positive**/negative/equivocal
*required only for oropharynx specimens
**positive p16 staining is defined as >70% diffuse strong nuclear and cytoplasmic staining
***negative p16 staining is defined as <50% diffuse strong nuclear and cytoplasmic staining
****equivocal p16 staining is defined as <70% but >50% diffuse strong nuclear and cytoplasmic staining.
EBV (Epstein Barr virus encoded RNA [EBER] or other)***.............. positive/negative ***required only for nasopharynx specimens
Pathologic stage (AJCC 8th ed.)..................................... pT__N__M__