Staging (Urethra)                                                        
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Pathologic Staging (pTNM)

CAP Approved Genitourinary • Urethra 4.0.0.0 (AJCC 8th ed.)

TNM Descriptors (required only if applicable) (select all that apply)

___ m (multiple primary tumors)

___ r (recurrent)

___ y (posttreatment)

Primary Tumor (pT) For male penile urethra and female urethra

___ pTX: 

Cannot be assessed

___ pT0: 

No evidence of primary tumor

___ pTa: 

Noninvasive papillary carcinoma

___ pTis: 

Carcinoma in situ 

___ pT1: 

Tumor invades subepithelial connective tissue 

___ pT2: 

Tumor invades any of the following: corpus spongiosum,   periurethral muscle

___ pT3: 

Tumor invades any of the following: corpus cavernosum, beyond  prostatic capsule, anterior vagina, bladder neck

___ pT4: 

Tumor invades other adjacent organs (eg, invasion of the bladder wall)

Primary Tumor (pT) For urothelial carcinoma of the prostatic urethra

___ pTX:         Cannot be assessed

___ pT0:         No evidence of primary tumor

___ pTa:  Noninvasive papillary carcinoma

___ pTis pu:  Carcinoma in situ, involvement of prostatic urethra 

___ pTis pd:  Carcinoma in situ, involvement of prostatic ducts

___ pT1: 

Tumor invades subepithelial connective tissue (only applied to tumors  invading from the urethral lumen)#

___ pT2: 

Tumor invades any of the following: prostatic stroma, corpus  spongiosum, periurethral muscle

___ pT3: 

Tumor invades any of the following: corpus cavernosum, beyond  prostatic capsule, bladder neck (extraprostatic extension)

___ pT4: 

Tumor invades other adjacent organs (invasion of the bladder)

# Tumors invading directly from prostatic ducts colonized by carcinoma in-situ are designated as at least pT2, regardless of depth or extent of invasion (i.e., there is no pT1 category in that setting). 


Regional Lymph Nodes (pN)

___ pNX:         Cannot be assessed

___ pN0:         No regional lymph node metastasis

___ pN1:         Metastasis in a single lymph node 2 cm or less in greatest dimension

___ pN2:         Metastasis in a single lymph node more than 2 cm in greatest dimension, or in multiple nodes

Distant Metastasis (pM)

___ Not applicable

___ pM1: Distant metastasis (specify site(s) if known)


Urethra CAP 4.0.0.0 summary of pTNM changes AJCC 7th to 8th edition


Genitourinary


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